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Immune cells, such as T-cells and Natural Killer cells, require adequate glutathione to multiply and respond to challenges effectively

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Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice

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Meanwhile, their downstream molecules, such as eIF2 and GADD153/CHOP, were also elevated, ultimately resulted in apoptosis

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