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Semaglutide binds to GLP-1 receptors throughout your body, particularly in the hypothalamus where appetite regulation occurs

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Drugs acting on the GLP-1 and on the PYY receptors deserve further investigation, because of the link between GLP-1 release and nausea, and the link between PYY release and postprandial fullness ( In summary, there is a clear need for in-depth evaluation of release of GI peptides after a standard meal in larger sample sizes of Rome IV PDS and EPS and gastroparesis patients

10.1152/ajpcell.00096.2014 115 LiuQ

If so, an intriguing possibility is that arousal-induced changes in the metabolic disposition of brain choline moieties leads to increased choline entry into MRS-invisible compartments without a proportionate increase in soluble choline uptake across the BBB

10.1016/j.celrep.2017.05.020 49 Dias-GunasekaraS.GubbensJ.Van LithM.DunneC.WilliamsJ