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We assessed six rodent models of ASD as part of this translational study, and showed that the abnormality seen in individuals with ASDnamely a striatal glutamate deficitwas recapitulated in VPA-exposed mice, Nlgn3 R451C KI mice, and Nlgn3 KO rats

The authors concluded that 1-year treatment outcomes for TNF inhibitor monotherapy and csDMARD co-therapy were very similar, although certain subgroups of patients (for example, those with peripheral arthritis) might benefit from co-therapy 96

Iron absorption, storage, and utilization processes are all integral to the regulation of ferroptosis

These p62 condensates recruit and sequester Keap1, facilitating its degradation and inhibiting Keap1-mediated Nrf2 degradation

M., Oh B., et al