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The observations reported herein show that pro-GSH molecules represent new therapeutic agents to support immune modulation. [222] These data indicate that glutathione peroxidase-dependent control of intracellular reactive oxygen species accumulation is important not only for regulation of TH-cell proliferation, but also for modulation of differentiation into TH1, TH2 and TH17 cells.[223] See the clinical strategies described above for strategies for increasing glutathione levels

In contrast, a clinical trial specifically testing N-acetylcysteine in 43 patients with probable Alzheimers disease reported that N-acetylcysteine (50 mg/kg/day) for 6 months failed to significantly alter MMSE scores, which were the primary outcome measures (18)

12), consistent with the findings in HCC cells

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