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14.2 Consensus recommendations 14.2.1 The transjugular approach for liver biopsy can be used in children in the setting of autoimmune-induced acute liver failure (LOE 4, Weak recommendation)

Acknowledgements This work was supported by the US National Institutes of Health grant T32HL066987 (F.D.), a Scholar Fellowship from Coordenao de Aperfeioamento de Pessoal de Ensino Superior (CAPES) and the David Rockefeller Center for Latin American Studies at Harvard University (R.T.G.), a Science Without Borders Scholar Fellowship from Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) (R.B.P.) and the Brazilian National Institute of Science and Technology for Vaccines grant CNPq/Fapemig/MS 573547/2008-4 (R.T.G.)

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As the epitopes of VNAR D1 and C4 were confirmed through crystallography as being distinct, two monoparatopic tetravalent Fc fusion protein, ELN22-129 (4x D1) and ELN22-130 (4x C4), were assessed for binding to sTNF- (Fig

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