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Notably, preclinical studies have shown that AAV- NaV1 treatment reduces mortality by 40% in female Scn1a+/ mice and ameliorates hyperactivity/anxiety-like behaviors in males, with this sex-dependent efficacy linked to baseline differences in GABAergic neuronal activity between sexes

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Funnel plot asymmetry and Eggers tests suggested potential small-study effects in some datasets (HDRS, BDI), raising concerns about publication bias

TABLE 2 Neurogenic inflammation in patients with migraine

interquartile range, 7811,354) than during nonmetabolic events (median, 642 ng/mL