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doi: 10.1080/21505594.2019.1685640 40 UrsiniF.MaiorinoM.Brigelius-FloheR.AumannK

Villaverde A, Estvez M (2013) Carbonylation of myofibrillar proteins through the maillard pathway: effect of reducing sugars and reaction temperature

Sci Rep 9(1):3964

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FoxO1-deficient -cells lose their identity and revert to pancreatic endocrine progenitors characterized by expressing high levels of neurogenin-3 (Neurog3 high ), and no insulin and MafA expression 22

GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]