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high-dose oral B12 can be effective for many causes of deficiency Sublingual (under the tongue) preparations : Though marketed as having better absorption, evidence does not show clear advantages over standard oral tablets Intramuscular injections : Prescribed for those with absorption problems or severe deficiency

NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)

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The options available provide an opportunity to target specific goals such as boosting energy levels or improving metabolic functions efficiently

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