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the product information notes that refrigeration can cause a color change (darker yellow) which does not affect safety or effectiveness

* Correspondence: Yun Kim, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Both plugs and plaque act as the platform for further deposition of crystals eventually developing into the stones