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Week two is when things shifted

10.1038/nm.3871 44 FanQ.ChangH.TianL.ZhengB.LiuR.LiZ

Melatonin and sorafenib together led to greater leukaemia cell depletion in peripheral blood smears and greater reductions in spleen and liver weight in mice as compared to mice treated with sorafenib alone (Tian et al., 2019)