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The CNS has a high demand for blood supply, and blood components such as red blood cells and hemoglobin (Hb) eventually degrade into iron

IMP also induces the expression of TGF-1 and activates phosphorylation of Smad-3 and Erk1/2, contributing to inflammatory damage in MCs and renal fibrosis [80]

Pharmacopuncture 22 (2), 5567

Apart from the ETM1 locus, ETM2 (OMIM: 602134) [ 69 ] and ETM3 (OMIM: 611456) [ 70 ] have also been considered as causal genetic factors for ET in a genome wide linkage scan, without though, as in case of ETM1 locus, the genes and the causal mutations for both, ETM2 and ETM3, loci being identified [ 3 ]

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