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Experimental based evidence [edit] Studies on rodents show that the response to neuronal injury due to acute sleep deprivation is adaptative before three hours of sleep loss per night and becomes maladaptative, and apoptosis occurs after

Neil Rawlins says it may take some as many as 4 months (at a therapeutic dose - for some that is as much as 15 mg) to notice that they are actually feeling better

Next 48 to 72 hours Most people see improvements across this window

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Listening to your body and adjusting as needed can help minimize these minor effects

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