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the AITC treatment increased even more the difference for pad2-1 through the concentration range than for the WT, whereas the reduction between the two highest doses of BSO was less pronounced on the mutant compared to WT

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Other cell types, such as macrophages and erythropoietic cells have special requirements for iron handling, as they accommodate the large iron fluxes associated with the recycling of iron from senescent red blood cells and hemoglobin synthesis, respectively