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Systemic metabolic alterations and their relationship to neuropsychiatric symptomatology PAIS, including long COVID, as well as CFS and IMD, share the characteristic of systemic metabolic disturbances, which may be a sign of underlying multi-organ inflammation and exhaustion [31], and consequently may contribute to neuropsychiatric symptomatology, as many metabolites can cross the bloodbrain barrier (BBB) [30, 58] (e.g., short chain fatty acids (SCFAs) derived from the gut microbiota such as acetate [40], amino acids such as tryptophan [52] and also carnitine/acetylcarnitine can cross the BBB via transporters [59])

Research indicates that mitochondrial dysfunction is one of the initiating factors of axonal degeneration

Li L, Wang Y, Chen J, Cheng B, Hu J, Zhou Y, Gao X, Gao L, Mei X, Sun M, et al

This dysfunction permits microbial products, toxins, and excess lipids to reach the liver, triggering immune responses and hepatocellular injury

If youre making beef broth or lamb broth, you should brown any of the leftover meat or organ meat before putting it into a stock pot

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