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In SLE, there is mounting evidence of the critical involvement of this system in disease pathogenesis

The maximum reported dosage for general health is 6080 drops (3040 mg/day), aligning with the lower end of 0.5 mg/kg for the average person Methylene blue drops are often sold as a 1% solution (10 mg/mL), where 1 drop contains 0.5 mg

doi: 10.1080/87559129.2023.2230268 282 CuiSGuJLiuXLiDMaoBZhangHet al

Bibcode:2000PNAS...97.8841N

Cell viability was analyzed by microplate reader at 450 nm

This deletion abolishes IGFBP binding while preserving IGF-1R affinity, making DES locally hyperactive but highly labile (half-life of a few minutes)