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[3] Additionally, glycine itself appears to have direct insulin-sensitizing properties: it stimulates glucagon-like peptide-1 (GLP-1) secretion from intestinal L-cells, activates hepatic GLP-1 receptors, and modulates bile acid composition in ways that favor improved glucose homeostasis

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However, HDAC6 inhibitors are poorly soluble in water which restricts their bioavailability and BBB permeability

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In addition to direct effects on hepatic lipid synthesis, LXR repression exerts pleiotropic effects to reduce dyslipidemia