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At the maternalfetal interface, collagen is abundant in the extracellular matrix and is actively remodeled to support a healthy pregnancy

Nanomedicine 19 (9), 755777

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[PubMed: 25586162] 32

Furthermore, NO interaction with hydrogen bonds to Ser-339, Trp-683, Val-65, Asp-601, and Hem-801 was demonstrated by rutin and IL-6, as well as by helix A and helix D