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the C-terminal cleavage efficiency of the engineered split intein was not affected by the identity of the first residue of the C-extein (proline was found to be an exception), enabling SIRP to completely remove the purification tag and purify proteins with the native N termini

Therefore, the exact role of NK cells and NKT cells in AILI still needs further investigation

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The cells basically get tired of hearing the same signal and start to pull the receptors from their surface, making them less sensitive