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Discussion In the current study, SUN treatment protocol used to develop cardiotoxicity is confirmed by increasing heart weight, cardiac index and cardiotoxicity enzymatic indices, LDH and CK-MB, as well as severe histopathological changes which are manifested as scattered chronic inflammatory cells with focal fragmentation of myocardial fibers and loss of nuclei

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Use of opioid analgesics to relieve chronic pain can cause effects on organs outside the targets in the central nervous system

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The observations reported herein show that pro-GSH molecules represent new therapeutic agents to support immune modulation[21] Low GSH levels have been associated with many autoimmune and inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, Crohns disease, multiple sclerosis, psoriasis, and contact dermatitis

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