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The proteins accumulate postsynthetic modifications, especially resulting from oxidation, leading to formation of protein aggregates that scatter light

AGEs and methylglyoxal induce apoptosis and expression of Mac-1 on neutrophils resulting in platelet-neutrophil aggregation

Additionally, they have been shown to improve gastrointestinal symptoms and enhance the quality of life in PD patients (Li et al., 2025)

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For instance, canthaxanthin has been widely used for this purpose and has been strictly evaluated because of that, resulting in different limitations (European Food Safety Authority 2014)

For separate vials, each compound is reconstituted on its own