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Besides the contraindicated populations weve discussed in the previous safety section, berberine is likely not to be a suitable supplemental intervention for anyone seeking: Dramatic weight loss: Although berberine appears to have weight-reducing potential,32 33 it isnt the natures Ozempic that some of the marketing might have you believe.62 If you experience any weight loss on berberine, it will be through roundabout mechanisms and much more modest than what you can expect with something like a GLP-1 receptor agonist