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The ANLS hypothesis draws heavily on data from techniques that measure metabolites and oxygen directly in the brain parenchyma (e.g., microsensors, microdialysis), emphasizing the rapid dynamics of a local lactate and oxygen pool (Hu and Wilson, 1997

Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

doi: 10.3109/08830185.2013.839665 24 LiMYangLCaoJLiuTLiuX

Nose-only exposure for 1 or 2 weeks, using non-irritant concentrations as judged in short-term pilot experiments, is carried out, upon which lung functions are tested and biochemical and morphological signs of effects in the airways are determined

Fertility test The reproductive ability of 2- and 8-month-old male mice was assessed by co-caging with adult WT females at the ratio of 1:2 for 3 months

Timing Baseline Marker Copper and ceruloplasmin Why it matters Adds copper-status context when repeated high-exposure copper peptide use is being discussed