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Their distinct, disease-specific distribution in the brain and associations with SVD MRI markers observed in CADASIL suggest that they are indeed a marker of SVD

Supplementary Data 2 (download ZIP Official PDB reports for all three protein crystal structures

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In general, essential fatty acid deficiency (i.e., deficiency of both ALA and LA) has been observed only in patients with chronic fat malabsorption, cystic fibrosis, or those on parenteral nutrition without PUFA (86, 95) (see the article on Essential Fatty Acids)