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Slightly positive or near-neutral zeta potentials (approximately 10 to +10 mV) are generally preferred for systemic administration because highly cationic particles can strongly bind to the negatively charged endothelial glycocalyx and plasma proteins, causing aggregation, complement activation, and membrane damage (120)

Furthermore, inducing ferroptosis by inhibiting the cellular antioxidant system presents a potential therapeutic strategy for OS, as various anticancer agents exert their effects by targeting antioxidant system-related proteins such as GPX4 ( 3 Ferroptosis in bone microenvironment The bone microenvironment encompasses the local setting where bone tissue resides, comprising key cellular components such as osteoblasts, osteoclasts, and osteocytes within the tissue, along with adipocytes, vascular networks, immune cells, and an abundance of bone marrow and extracellular matrix (81)

Li, H., Guan, Y., Liang, B., Ding, P., Hou, X., Wei, W., & Ma, Y

doi: 10.1080/21655979.2021.2010369 65 LiSLiYWuZWuZFangH

By supporting GPx4 activity, L-Glutathione supplementation may help protect the mitochondria from structural collapse, supporting efficient ATP production

I wonder if it was also difficult for his father