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In stark contrast, exogenous lactate administration at moderate doses in experimental settings reveals a protective, pharmacodynamic potential

In the range of cells affected by the mutation in the GLA gene and contributing to the Fabry disease phenotype, endothelial cells also represent an important part

The availability of software applications to conveniently implement FBA and related in silico methods 20 has enabled the development of genome-scale models (GEMs) for more than 100 species across all three domains of life, thereby facilitating analysis of their intracellular metabolism 21

Effect of treatment on the number and size of bound GTP vesicles and rapid Nrf2 activation in 3xTg-AD hippocampal neurons We hypothesized that impaired vesicular endocytosis was caused by an energy shortage that resulted in a buildup of vesicles and possibly enlargement from failure to complete processing

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