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11 combined GC/MS-based untargeted urine metabolomics of samples collected from a group of children with ASD and a TD control group with the XGBoost algorithm to identify 20 potential metabolic biomarkers to distinguish between the groups, which were mapped to a variety of metabolic pathways

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moreover, differently methylated regions (both hypomethylated and hypermethylated) were found in the Sod3 gene (Hotta et al