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Kovacic P, Sacman A, Wu-Weis M: Nephrotoxins: widespread role of oxidative stress and electron transfer

Paunesku, T., Vogt, S., Maser, J., Lai, B

In other words, ferroptosis sensitivity is controlled by several metabolic and biochemical pathways and processes, including cysteine metabolism, glutathione metabolism and radical homeostasis (Figure 1)

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One mechanism involves the S-sulfhydation of OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) at Cys91, which stabilizes the Xc light chain subunit (xCT), thereby promoting cystine uptake and maintaining GSH biosynthesis [77]

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