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Hmostaseologie, 2024

Lu J, Li W, Du X, Ewert DL, West MB, Stewart C, Floyd RA, Kopke RD

For SARS-CoV-2 M pro we used our novel tetrapeptide QS1 fluorogenic substrate, that has a lower k cat /K M value (k cat /K M = 859 s 1 M 1 ) in comparison to FRET substrates 22

Studies highlight that vitamin B12, along with folate, is needed as a major determinant of one-carbon metabolism, which produces the compound called SAM-e ( S-adenosyl methionine)