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Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance

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typically improves with continued use 2 Skin irritation, stinging, or a warm sensation, especially in those with sensitive skin Increased sun sensitivity tretinoin makes the skin more vulnerable to UV damage

One reason for this may be that the body needs vitamin B12 to process homocysteine

Oxidative stress, assessed via the GSH/GSSG ratio, increased in both HepG2 and HepG2 ATP7B-KO cells across all copper doses