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Reproductive toxicity studies of acetylcysteine solution in the rat given oral doses of acetylcysteine solution up to 1,000 mg/kg (5.2 times the human mucolytic dose) have also been reported in the literature.1 The only adverse effect observed was a slight non-dose-related reduction in fertility at dose levels of 500 or 1,000 mg/kg/day (2.6 or 5.2 times the human mucolytic dose) in the Segment I study

Hu Q, Xu J, Wang L, Yuan Y, Luo R, Gan M, et al

Braz J Chem Eng

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Batch testing may include HPLC purity analysis, identity confirmation, and related analytical documentation depending on the current production batch

[Google Scholar] 52.High-dose acetylcysteine in idiopathic pulmonary fibrosis