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ABAT deletion did not result in T cell development defects in the thymus, the spleen or lymph nodes (Extended Data Fig

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B) GUT An abundant literature has implicated NO in the pathophysiology of gut I/R (GIR) injury

5mTHF-mediated inhibition has been demonstrated in vitro to involve the GNMT N-terminus, a highly conserved domain composed of a flexible tail (residues 1-8) followed by a structured U-loop (residues 9-22) proximal to the globular domain and SAM binding site, the latter of which functions as a gatekeeper for SAM entry 35,36