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Alterations in aerobic metabolism have been reported in fibroblasts involved in pulmonary fibrosis [166], particularly increased glycolysis, resistance to apoptosis, and propensity to develop a metabolic-driven fibrotic phenotype, which appears to be linked to decreased ATP synthesis and increased mtROS production [169, 170]

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GPx-4 is particularly important in maintaining the integrity of cellular membranes and is involved in various physiological processes, including apoptosis and the regulation of cellular redox status

While a substantial portion of Glu in the synaptic cleft is cleared by GLAST and neuronal GLT-1, there remains an excess of Glu within the synaptic cleft, influencing the postsynaptic neuronal excitability

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