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Clinical Status Human RCT | Observational | Animal | In vitro Primarily studied in preclinical senescence and longevity research models, with no large-scale human clinical trials

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Additional TME factors, including IL-6 and PD-1AhR signaling, exacerbate mtROS accumulation and promote metabolic exhaustion, ultimately leading to NK cell apoptosis and loss of intrahepatic tumor surveillance [11, 172]

10.1016/j.fertnstert.2013.05.004 113 Ruiz-AlonsoM.ValbuenaD.GomezC.CuzziJ.SimonC