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Neurotrophic factors (e.g., GDNF), 5-HT, and glial-derived signals have been shown to promote neurogenesis and circuit reorganization, offering novel avenues for ENS-targeted interventions in colitis

T., Breitkreutz D., Hornung J., Markham A., and Fusenig N

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The therapeutic application of the PBN mechanism in MI/R involves three key strategies: (1) Targeted enzymatic therapy employing the Targ-CD39 fusion protein, which binds activated GPIIb/IIIa to enhance capillary density in infarcted myocardium while concurrently preventing thrombosis and vascular occlusion [45, 46, 48]

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