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The homozygosity of T-DNA insertion mutants was verified by PCR using T-DNA specific and target specific primers (Supplementary Table S2)

Secondly, this study is an observational study, and therefore, the causality could not be concluded

highlighted a higher expression of MEG3 in GH-secreting pituitary adenomas with respect to non-functioning pituitary adenomas, where the expression was lost in most samples (70)

[12] [13] Notably, taurine can inhibit the liver enzyme CYP2E1, which is involved in the metabolism of many substances (including certain anesthetics, acetaminophen, and alcohol)

This regulatory pathway has also been studied and reviewed extensively (6, 17, 18, 29, 63, and references contained therein)

Pharmacological treatment of BD, which is of great importance in the clinical management of BD, has also critical effects on gut microbiota, opening the opportunity to use this knowledge as potential biomarkers