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Huang Q, Liu Z, Yang Y, Yang Y, Huang T, Hong Y, et al

2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005)

Source Data Extended Data Fig.5 (download XLSX Statistical source data

GPX4 inhibition enhances glioma radiosensitivity by inducing oxidative stress-dependent SSG and degradation of transglutaminase 2 (TGM2), impairing DNA repair 126

China has a high incidence rate of liver cancer [36], and viral infection [79], chronic alcoholism [50], eating moldy and deteriorate foods [116] can lead to hepatic cancer

The PD-L1/PD-1 interaction inhibits critical T cell signaling pathways (e.g., PI3K/AKT/mTOR), ultimately leading to exhaustion and apoptosis of the T cells, creating an immunosuppressive shield for tumors (88, 89)