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Therefore, HIF subunits are accumulated and activated to promote gene transcription

1,178,179 The goal of menopausal hormone therapy is to relieve symptoms, and the dosage of hormones should be adjusted based on the symptomatic response

However, interpretation remains cautious, as reproductive endpoints (ongoing pregnancy, live birth) are inconsistently reported and dosing (commonly 24 g/day), formulations (MI alone vs 40:1 MI: DCI), co-therapies, and trial quality vary widely, prompting calls for larger, standardized, phenotype-stratified studies

Chen C, Chen W, Nong Z, Nie Y, Chen X, Pan X

For many patients, the convenience and potential benefits outweigh the brief discomfort associated with the shot

Bezaire V, Bruce CR, Heigenhauser GJ, Tandon NN, Glatz JF, Luiken JJ, Bonen A, Spriet LL (2006) Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation