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This combined approach results in improved glycemic control and substantial weight reduction, with clinical trials demonstrating HbA1c reductions of 1.9% to 2.4% and weight loss of approximately 15% to 22% of body weight at the highest doses in specific trials such as SURMOUNT-1

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For very hydrophobic peptides the combined ether washes were re-extracted with DMF, allowed to precipitate peptide, and filtered to recover additional peptide

30:1013-1014, Wright RS, Levine MS, Bellamy PE, Simmons MS, Batra P, Stevenson LW, Walden JA, Laks H, Tashkin DP

Boston, Massachusetts, April 26, 2008

Gan L, Wang J, Jiang M, et al