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Current Neuropharmacology , 2017 Reviewed neuroprotective effects and modulation of dopaminergic and serotonergic pathways in preclinical models

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These include the derivatives of D-Nle-X-Ile- (6) amino-hexanoic amide, an AngFV-based analog family, where X= Tyr, Cys, Trp, and Met

74,77 A study in fibromyalgia patients showed their muscle oxygen use was lower, a possible sign of reduced mitochondrial energy production, and did not increase during exercise

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This balanced effect on coagulation pathways suggests potential applications in conditions involving both thrombosis risk and bleeding concerns