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It turns out that there are a large number of people (anywhere from 20 to 40% (3)) who have small genetic mutations which impact how well this process works

On enterocytes and monocytes, gliadin binds to the CXCR3 chemokine receptor, which provides a signal for the cell to increase zonulin synthesis

PMID: 3603115

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At the same time, it blocks lipogenesis, preventing new fat storage

They bind to specific receptors on cell surfaces, triggering downstream signaling cascades that regulate everything from growth and metabolism to immune responses and neurological function