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The ideal energy intake should be neutral or slightly positive, tailored to individual energy expenditure, preferably determined by indirect calorimetry or predictive equations corrected for thyroidal status [193, 194]

Blood 88 : 386401 Weller M, Winter S, Schmidt C, Esser P, Fontana A, Dichgans J and Groscurth P (1997) Topoisomerase I inhibitors for human malignang glioma: differential modulation of p53, p21, bax and Bcl-2 expression and of CD95-mediated apoptosis by camptothecin and beta lapachone

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The pattern that emerges across this research is that L-Carnitine appears to help most in people who either have lower baseline carnitine levels (such as vegetarians) or who are engaging in regular exercise that creates genuine demand for fat oxidation

GHK-Cu solves this by binding copper tightly enough to prevent oxidative damage but loosely enough to deliver it where cells need it