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Went to bed early and woke up at 1am with a racing heart( which should not happen as Im on a beta blocker), chest tightness, difficulty breathing, my fingers and tongue were either tingling like pins and needles or numb

The consequences can be as severe as triggering autoimmune diseases or compromising your body's ability to fight infections

PubMed PMID: 10730193

The exact cause of perioral dermatitis is not known

DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon

Ice crystals physically damage peptide structures