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Monocle2 pseudotime analysis further confirmed that, relative to natural aging, the additional effect of HHcy caused endothelial cells to diverge in different directions and accelerated their transition from pre-aging to senescence, as evidenced by the bifurcation at Branch Point 1 (Figure 2K)

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"The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)." J Am Coll Cardiol 55 (2010): 2319-2327

(ii) In eukaryotes, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMG synthase 2) catalyzes the condensation of acetoacetyl-CoA with a third acetyl-CoA to form HMG-CoA (Bahnson, 1960

From the size and sequence diversity within the GST superfamily in Arabidopsis , it is clear that there is scope for considerable functional diversification

Altogether, by enabling the TCA cycle, Fe-S clusters take part in the controlled combustion of nutrients and supply metabolic precursors for nucleotide, lipid, and protein biogenesis