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Participating hospitals were Alberta Childrens Hospital (Calgary), Stollery Childrens Hospital (Edmonton), British Columbia Childrens Hospital (Vancouver), Childrens Hospital of Eastern Ontario (Ottawa), and Centre Hospitalier Universitaire (CHU) Sainte-Justine (Montreal)

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Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice

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Metformin can affect the malignant behaviour of SMAD4-deficient PDAC cells by inhibiting HNF4G activity [310]