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William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

Refrigeration is recommended

People Who Have Had Gastric Surgery Gastric bypass surgery (like Roux-en-Y), sleeve gastrectomy, or other bariatric procedures significantly reduce the stomachs ability to produce intrinsic factor a protein required to absorb B12 in the small intestine

Its complex nature and diverse applications make it a vital aspect of medical study and therapeutic application

Riboflavin (B2)

B12 is safe for most, but interactions should be reviewed