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Acknowledgments The authors are grateful to David Lynch for the invitation to contribute this review to the research topic Basic and Clinical Mechanisms in Friedreich Ataxia. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Monitor for deterioration: If vision worsening despite peptides, don't assume peptides need more time

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Bioactive compounds with antioxidant properties can act as reductants, neutralizing oxidants in the process (Koksal and Gulcin 2008)

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J Pain Symptom Manage