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The STEP-1 trial tested the effect of high-dose semaglutide to produce weight loss in people with obesity who do not have diabetes

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However, it only increases the percentage of the EFSAs acute reference dose (ARfD) of 20 g/kg body weight from 7.4% to 8.9% (lower bound) or from 13% to 15% (upper bound), which is negligible for people with normal kidney function

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Because many of these symptoms overlap with other post-operative complaints such as fatigue from dietary restriction or iron deficiency B12 deficiency can sometimes be overlooked