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Daily administration of two or more synaptogenic compounds simultaneously might overwhelm cellular synthetic capacity or trigger compensatory downregulation faster than either compound would alone, potentially favoring alternating administration schedules where different compounds are used on different days

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Difficulty breathing, facial swelling, or a spreading rash requires immediate evaluation

(1984) found that sodium thiosulfate (12 g/m 2 ) could be given safely to humans over 6 h provided that cardiac and renal functions were normal

Studies show 15-25% increases in receptor density after 3-6 months of reduced stimulation

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