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Description

These mice had a reductive stress phenotype [46, 47], characterized, in part, by an increased activity of GPx1 and catalase as well as increased GSH/GSSG and a corresponding increased expression of enzymes involved in glutathione biosynthesis and GSSG recycling to GSH

The treatment leverages Semaglutide GLP-1s proven efficacy to help achieve substantial weight loss

Hepatology 42(3):665674

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Additional information regarding clinical outcomes as a result of treatment with SER-109 compared to such treatment options, instead of placebo, would be helpful in our assessment of the substantial clinical improvement criterion