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A statistically significant increase in cancer was observed in rats receiving semaglutide at all dose levels (greater than 2X human exposure)

One individual per group was euthanized before addressing the next animal in each group to render differences arising from the time of day at euthanization (e.g., cecal mass changes resulting from differences in time post-food consumption) comparable across all groups

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Medicare tends to follow a stricter line, often requiring detailed diagnosis support